![]() Lipids are important biomolecules implicated as contributing factors in many diseases, including those associated with circadian disruption. ![]() 6 As such, long-term night-shift workers are at elevated risk of developing several of the most common chronic diseases. ![]() 4, 5 Research has shown that negative health impacts of circadian disruption can occur years after altered behavioral cycles. 3 Challenges to this interplay due to altered behavioral cycles, such as in night-shift work, can cause circadian disruption resulting in metabolic misalignment and increased risk of multiple metabolic diseases including cardiovascular disease (CVD). These peripheral clocks are tightly linked to metabolism, enabling physiological adjustments of metabolic needs. 2 The SCN send signals via neural and hormonal cues to peripheral clocks throughout the body that regulate physiologic processes. 1 The mammalian circadian clock originates from the central pacemaker in the hypothalamic suprachiasmatic nuclei (SCN), where it receives light signals from the environment synchronizing it to 24 h light/dark cycles. ![]() Circadian control at the system level coordinates behavioral patterns such as sleep-wake and feeding-fasting cycles.
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